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It may also be called a COX-2 inhibitor or a sulfonamide. Celebrex is a nonsteroidal anti-inflammatory drug (NSAID). One difference between Aleve and Celebrex is that Aleve is available without a prescription from your doctor ( over-the-counter, OTC) and Celebrex is not. It works by reducing hormones that cause farxiga medication alternatives inflammation and pain in the body. Upsides Effective for the relief of acute pain, including period pain (primary dysmenorrhea) and postoperative (eg, dental or orthopedic) pain This risk may occur early in the treatment and may increase with duration of use. Aliquam tempus Consuming liquor can only boost the risk of belly blood loss Tylenol or acetaminophen is the most widely used over-the-counter (OTC) analgesic used in America and around the globe. This medication was first distributed in 1955 as Tylenol Elixer for children, and today millions of adults and children use Tylenol for common ailments such as pyrexia, head and body ache and inflammation. Mission & History; Strategic Plan; Keep America Beautiful Positions; How Donations are Used; Annual Reports; Our Team. Celecoxib is contraindicated in the setting of coronary artery bypass graft (CABG) surgery. Aleve ( naproxen) and Celebrex ( celecoxib) are nonsteroidal anti-inflammatory drugs ( NSAIDs) used to treat arthritis, pain, menstrual cramps, and fever.