Verapamil side effects in elderly
Verapamil side effects in elderly
Pregnancy Category C [23] Use during pregnancy may cause adverse effects on the fetus (e. Lung problems-- anxiety, sweating, pale skin, wheezing, gasping for breath, cough with foamy mucus. At variance with the conclusions from several other studies, we think that it is too early to conclude that CCB are not associated with cancer. VERAPAMIL (ver AP a mil) treats a fast or irregular heartbeat (arrhythmia). It works by decreasing your heart rate, which decreases the amount of work your heart has to do. Pharmacokinetics and pharmacodynamics of verapamil were studied in 11 elderly subjects (age=79. Adverse effects, such as a postural hypotension, may be more frequent in elderly compared with can i take acyclovir and tylenol together younger patients Many elderly patients are on beta-blockers, perhaps to their detriment. In hypertensive patients, decreases in blood pressure below normal are unusual Verapamil, but not dihydropyridines, decreases mortality after myocardial infarction in patients without congestive heart failure. High blood pressure may also increase the risk of heart attacks. A problem with menstrual periods. 37 years) following intravenous (IV), single verapamil side effects in elderly oral, and long-term oral administration. As a first-line antihypertensive agent, oral verapamil is equivalent to several other calcium antagonists, beta-blockers, diuretics, angiotensin-converting enzyme (ACE) inhibitors and other vasodilators, and is not associated with many of the common adverse effects of these treatments. Verapamil, but not dihydropyridines, decreases mortality after myocardial infarction in patients without congestive heart failure. It belongs to a group of medications called calcium channel blockers. Temporary redness of face and neck. Occasionally, the pharmacologic action of verapamil may produce a decrease in blood pressure below normal levels which may result in dizziness or symptomatic hypotension. In line with earlier studies, however, we found an increased risk verapamil side effects in elderly of cancer in users of verapamil. However, elderly patients are more likely to have age-related heart, liver, or kidney problems which may require an adjustment of dose in patients receiving verapamil. The incidence of hypotension observed in 4,954 patients enrolled in clinical trials was 2. , bradycardia, heart block, hypotension). Treatment choices for hypertension can have an enormous impact on outcomes among older patients: Two thirds of US adults 60 years of age and older have hypertension, mostly isolated systolic hypertension. In the elderly group, after long-term oral administration, there was a significant prolongation of the P-R interval (p. Geriatric Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of verapamil in the elderly. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have. Twenty-four hour dynamic Holter electrocardiographic (ECG. Call your doctor for medical advice about side effects a problem with menstrual periods. [22] Verapamil can cross the placenta. Plasma verapamil concentrations were determined using high-pressure liquid chromatography (HPLC). In the AVERROES trial, the rate of stroke/SE was significantly reduced with apixaban, compared to aspirin, with similar effects on major bleedings or ICH, irrespective of age. In both analyses, however, verapamil was significantly associated with cancer with RRs of 2. Verapamil should not be used in those with HCM and systemic hypotension or severe difficulty breathing at rest. Heart throbbing or pounding Geriatric Appropriate studies performed to date have not demonstrated geriatrics-specific problems that would limit the usefulness of verapamil in the elderly. MeSH terms Aged Calcium Channel Blockers / adverse effects* Cardiovascular Diseases / drug therapy. 9), respectively, whereas no associations were found with the other CCB in this study, i. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. Verapamil may be preferred as an alternative first-line. Calcium antagonists have not been shown to be beneficial in the treatment of acute stroke.